The founding of this city is attributed to the seer Mopsus, from whom the city also took its name, who lived before the Trojan war, although it is scarcely mentioned before the Christian era. Pliny the Elder calls it the free city of Mopsos (Hist. nat., V, 22), but the ordinary name is Mopsuestia, as found in Stephanus of Byzantium and all the Christian geographers and chroniclers. Under the Seleucid Empire, the city took the name of Seleucia on the Pyramus (classical Greek: Σελεύκεια πρὸς τὸν Πύραμον, Seleukeia pros ton Pyramon; Latin: Seleucia ad Pyramum), but gave it up at the time of the Roman conquest; under Hadrian it was called Hadriana, under Decius Decia, etc., as we know from the inscriptions and the coins of the city. Constantius II built there a magnificent bridge over the Pyramus (Malalas, Chronographia, XIII; P.G., XCVII, 488) afterwards restored by Justinian (Procopius, De Edificiis, V. 5) and has been restored again recently.
Christianity seems to have been introduced very early into Mopsuestia, and during the 3rd century there is mention of a bishop, Theodorus, the adversary of Paul of Samosata. Other famous residents of the early Christian period in the city's history include Saint Auxentius (d. 360), and Theodore, bishop from 392–428, the teacher of Nestorius. The bishopric is included in the Catholic Church's list of titular sees. Along with much of Cilicia, the region was wrested from Roman control by the Arabs in the late 630s.
In 684 the Emperor Constantine IV recaptured Misis from its small Arab garrison and it remained an imperial possession until 703 (Theophanes,
"Chronogr.", A. M. 6178, 6193), when it was recaptured by the Arabs,
who rebuilt the fortifications, constructed a mosque, and maintained a
permanent garrison. Because of its position on the frontier, the city was repeatedly fought over and was recaptured from time to time by the Byzantines: it was besieged in vain by the Byzantine troops of John I Tzimisces in 964, but was taken the following year after a long and difficult siege by Nicephorus Phocas.
Mopsuestia then numbered 200,000 inhabitants, some of whom were Muslim,
and the Byzantines made efforts to re-Christianize the city. In the
early 1090s Turkish forces overran the town, but were expelled in 1097
by Crusader troops under Tancred who took possession of the city and its strategic port, which were annexed to the Principality of Antioch.
It suffered much from internecine war between Crusaders, Armenians,
and Greeks who lost it and recaptured it, notably in 1106, 1132, and
1137. Finally in 1151–1152 the Armenian Baron T'oros II captured the
city and defeated the Greek counter attack led by Andronikos I Komnenos. Thereafter it remained a possession of the Armenian Kingdom of Cilicia,
but was briefly captured and plundered by the Mamluks in 1266, 1275,
and 1322. The Venetians and Genoese were licensed by the Armenians to
maintain warehouses near the harbor to store goods brought from India.
The Armenians were permanently evicted by the Mamluks in 1347. The city was the site of several church councils and possessed four Armenian churches; the Greek diocese still existed at the beginning of the fourteenth century (Le Quien, Oriens Christianus, II, 1002). In 1432 the Frenchman Bertrandon reported that the city was ruled by the Muslims and was largely destroyed. In 1515 Mopsuestia, and the whole of Cilicia, was incorporated into the Ottoman Empire by Sultan Selim I. Since then it has steadily declined and became the small village of Misis. Misis was renamed Yakapınar
in the 1960s. Only fragments of the medieval fortifications survive
today. However, an etching of the circuit walls and towers was made in
the mid-19th century. The Misis Mosaic Museum was founded in 1959 to exhibit the mosaics found in the area, including the famous "Samson Mosaic."